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7
Mechanism of Action of KL-50, a Novel Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers
Huseman, E. D.; Lo, A.; Fedorova, O.; Elia, J. L.; Gueble, S. E.; Lin, K.; Sundaram, R. K.; Oh, J.; Liu, J.; Menges, F. S.;
Rees, M. G.; Ronan, M. M.; Roth, J. A.; Batista, V. S.; Crawford, J. M.; Pyle, A. M.; Bindra, R. S.*; Herzon, S. B.*
J. Am. Chem. Soc. 2024, 146, 18241–18252. DOI: 10.1021/jacs.3c06483
Highlighted as the JACS cover art.
Highlighted in C&EN (2024, 102, 6).
6
Mechanism-based Design of Agents that Selectively Target Drug-Resistant Glioma
Lin, K.; Gueble, S. E.; Sundaram, R. K.; Huseman, E. D.; Bindra, R. S.*; Herzon, S. B.*
Science 2022, 377, 502–511. DOI: 10.1126/science.abn7570
3
Luteolin Decreases EGFR-Mediated Cell Proliferation and Induces Apoptosis in Glioblastoma Cell Lines.
Anson, D. M.; Wilcox, R. M.; Huseman, E. D.; Stump, T. A.; Paris, R. L.; Darkwah, B. O.; Lin, S.; Adegoke, A. O.;
Gryka, R. J.; Jean-Louis, D. S.; Amos, S.*
Basic. Clin. Pharmacol. Toxicol. 2018, 123, 678–686. DOI: 10.1111/bcpt.13077
2
The DARK Side of Total Synthesis: Strategies and Tactics in Psychoactive Drug Production
Chambers, S. A.; DeSousa, J. M.; Huseman, E. D.; Townsend, S. D.*
ACS Chem. Neurosci. 2018, 9, 2307–2330. DOI: 10.1021/acschemneuro.7b00528
5
Synthesis and Cytotoxic Evaluation of Arimetamycin A and Its Daunorubicin and Doxorubicin Hybrids
Huseman, E. D.; Byl, J. W.; Chapp, S. M.; Schley, N. D.; Osheroff, N.; Townsend, S. D.*
ACS Cent. Sci. 2021, 7, 1327–1337. DOI: 10.1021/acscentsci.1c00040
Highlighted in Synfacts (2021, 17, 1268).
4
De novo Synthesis of an ÊŸ-Lemonose Thioglycoside Donor from á´…-Threonine
Huseman, E. D.; Townsend, S. D.*
Tetrahedron Lett. 2021, 73, 153097. DOI: 10.1016/j.tetlet.2021.153097
1
Synthesis and Characterization of a Series of Chiral Alkoxymethyl Morpholine Analogs
as Dopamine Receptor 4 (D4R) Antagonists
Witt, J.; McCollum, A. L.; Hurtado, M. A.; Huseman, E. D.; Jeffries, D. E.; Temple, K. J. Plumley, H. C.;
Blobaum, A. L.; Lindsley, C. W.; Hopkins, C. R.*
Bioorg. Med. Chem. Lett. 2016, 26, 2481–2488. DOI: 10.1016/j.bmcl.2016.03.102
